HEREDITARY BREAST AND OVARIAN CANCER 6/2/07
Personal or family history of:
- Breast Cancer before age 50
- Ovarian cancer at any age
- Bilateral breast cancer at any age
- Both breast cancer and ovarian cancer at any age
- Male breast cancer at any age
- Askenazi Jewish ancestry with breast or ovarian cancer at any age
- > or = to 50 y/o w/breast cancer and a family history of breast and/or ovarian cancer.
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| Recommendations from the United States Preventive Services Task Force on who should be offered genetic testing for BRCA mutations=================================================
| A family history of breast or ovarian cancer that includes a relative with a known deleterious BRCA mutation |
| For non-Ashkenazi Jewish women: |
| Two first-degree relatives with breast cancer, one of whom was diagnosed at age 50 or younger |
| A combination of three or more first or second-degree relatives with breast cancer regardless of age at diagnosis |
| A combination of both breast and ovarian cancer among first and second-degree relatives |
| A first-degree relative with bilateral breast cancer |
| A combination of two or more first or second degree relatives with ovarian cancer, regardless of age at diagnosis |
| A first or second-degree relative with both breast and ovarian cancer at any age |
| History of breast cancer in a male relative===================================================== |
| For women of Ashkenazi Jewish descent: |
| Any first-degree relative (or two second degree relatives on the same side of the family) with breast or ovarian cancer |
U.S. Preventive Services Task Force. Genetic risk assessment and BRCA mutation testing for breast and ovarian cancer susceptibility: recommendation statement. Ann Intern Med 2005; 143:355. |
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