Early HRT Use Linked to Reduced Risk of Alzheimer’s Disease, All-Cause Dementia

May 4, 2007 (Boston) — New research from the Women’s Health Initiative Memory Study (WHIMS) links use of hormone replacement therapy (HRT) before the age of 65 years to a reduced risk of all-cause dementia and Alzheimer’s disease (AD) in women.

However, investigators warn these findings should be interpreted with caution and, at this point, have no clinical implications or indicate a need to modify current HRT guidelines.

Here at the American Academy of Neurology 59th Annual Meeting, researchers presented an analysis that showed early HRT us was associated with a 46% overall reduction in dementia risk and a 64% reduction in Alzeimer’s Disease .

“These findings are observational and have implications in terms of informing some of the research that needs to be done to determine the long-term cognitive outcomes of early HRT usage. But they do not inform clinical practice,” said Victor Henderson, MD, from Stanford University in Palo Alto, California.

“The current recommendations to use hormone replacement therapy for the treatment of moderate to severe vasomotor symptoms associated with menopause at low doses and for a shorter duration are still appropriate,” he added.

This entry was posted on Friday, December 26th, 2008 at 5:47 pm and is filed under (HRT) Hormone Replacement Therapy, Gynecology, Menopause. You can follow any responses to this entry through the RSS 2.0 feed. Both comments and pings are currently closed.